Interleukin 20 receptor, alpha subunit

Interleukin 20 receptor, alpha

Identifiers

IL20RA; FLJ40993; IL-20R1; ZCYTOR7

External IDs

OMIM: 605620 MGI: 3605069 HomoloGene: 8685 GeneCards: IL20RA Gene

Gene Ontology
Molecular function	• receptor activity
Cellular component	• membrane • integral to membrane
Biological process	• blood coagulation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
137.32 – 137.37 Mb

Chr 10:
19.43 – 19.48 Mb

PubMed search

[1]

[2]

Interleukin 20 receptor, alpha subunit is a subunit for the interleukin-20 receptor. IL20RA is its human gene.^[1]

The protein encoded by this gene is a receptor for interleukin 20 (IL20), a cytokine that may be involved in epidermal function. The receptor of IL20 is a heterodimeric receptor complex consisting of this protein and interleukin 20 receptor beta (IL20B). This gene and IL20B are highly expressed in skin. The expression of both genes is found to be upregulated in Psoriasis.^[1]

References

^ ^a ^b "Entrez Gene: IL20RA interleukin 20 receptor, alpha". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53832.

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Xie MH, Aggarwal S, Ho WH et al. (2000). "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R". J. Biol. Chem. 275 (40): 31335–31339. doi:10.1074/jbc.M005304200. PMID 10875937.
Blumberg H, Conklin D, Xu WF et al. (2001). "Interleukin 20: discovery, receptor identification, and role in epidermal function". Cell 104 (1): 9–19. doi:10.1016/S0092-8674(01)00187-8. PMID 11163236.
Dumoutier L, Leemans C, Lejeune D et al. (2001). "Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types". J. Immunol. 167 (7): 3545–9. PMID 11564763.
Wang M, Tan Z, Zhang R et al. (2002). "Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2". J. Biol. Chem. 277 (9): 7341–7347. doi:10.1074/jbc.M106043200. PMID 11706020.
Parrish-Novak J, Xu W, Brender T et al. (2003). "Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions". J. Biol. Chem. 277 (49): 47517–47523. doi:10.1074/jbc.M205114200. PMID 12351624.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Clark HF, Gurney AL, Abaya E et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
Mungall AJ, Palmer SA, Sims SK et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–811. doi:10.1038/nature02055. PMID 14574404.
Pletnev S, Magracheva E, Kozlov S et al. (2003). "Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20". Biochemistry 42 (43): 12617–12624. doi:10.1021/bi0354583. PMID 14580208.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Sheikh F, Baurin VV, Lewis-Antes A et al. (2004). "Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2". J. Immunol. 172 (4): 2006–10. PMID 14764663.
Hör S, Pirzer H, Dumoutier L et al. (2004). "The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains". J. Biol. Chem. 279 (32): 33343–33351. doi:10.1074/jbc.M405000200. PMID 15178681.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–2824. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2286551.

Transmembrane receptors: Immunoglobulin superfamily immune receptors

Antibody receptor:
Fc receptor

Epsilon (ε)	FcεRI · (FcεRII is C-type lectin)

Gamma (γ)	FcγRI · FcγRII · FcγRIII · Neonatal

Alpha (α)/mu (μ)	FcαRI · Fcα/μR

Secretory	Polymeric immunoglobulin receptor

Antigen receptor

B cells

Antigen receptor	BCR

Co-receptor	stimulate: CD21/CD19/CD81 inhibit: CD22

Accessory molecules	Ig-α/Ig-β (CD79)

T cells

Ligands	MHC (MHC class I and MHC class II)

Antigen receptor	TCR: TRA@ · TRB@ · TRD@ · TRG@

Co-receptors	CD8 (with two glycoprotein chains CD8α and CD8β) · CD4

Accessory molecules	CD3 · CD3γ · CD3δ · CD3ε · ζ-chain (also called CD3ζ and TCRζ)

Cytokine receptor

see cytokine receptors

Killer-cell IG-like receptors

KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DL5B, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KIR3DS1

Leukocyte IG-like receptors

LILRA1 · LILRA2 · LILRA3 · LILRA4 · LILRA5 · LILRA6 · LILRB1 · LILRB2 · LILRB3 · LILRB4 · LILRB5 · LILRA6 · LILRA5

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

M: LMC

cell/phys/auag/auab/comp, igrc

imdf/ipig/hyps/tumr

proc, drug(L3/4)

Cytokine receptors

Chemokine receptor
(GPCRs)

CC	CCR1/CCRL1 · CCR2 · CCRL2 · CCR3 · CCR4 · CCR5 · CCR6 · CCR7 · CCR8 · CCR9 · CCR10

CXC	IL-8 (CXCR1, CXCR2) · CXCR3 · CXCR4 · CXCR5 · CXCR6 · CXCR7

Other	CX3C (CX3CR1) · XC (XCR1) · CCBP2 · CMKLR1

TNF receptor

1-10	TNFRSF1 (CD120) · TNFRSF1A (CD120a) · TNFRSF1B (CD120b) · TNFRSF3 (Lymphotoxin beta receptor) · TNFRSF4 (CD134) · TNFRSF5 (CD40) · TNFRSF6 (FAS) · TNFRSF6B · TNFRSF7 (CD27) · TNFRSF8 (CD30) · TNFRSF9 (CD137)

11-20	TNFRSF10A (CD261) · TNFRSF10B (CD262) · TNFRSF10C (CD263) · TNFRSF10D (CD264) · TNFRSF11A (CD265/RANK) · TNFRSF11B (Osteoprotegerin) · TNFRSF12A (CD266) · TNFRSF13B (CD267) · TNFRSF13C · TNFRSF14 (CD268) · TNFRSF16 (Nerve growth factor receptor) · TNFRSF17 (CD269) · TNFRSF18 · TNFRSF19

21-25	TNFRSF21 · TNFRSF25 · TNFRSF27

JAK-STAT

Type I

γ-chain	Interleukin receptors (IL2R/IL2RA/IL2RB/IL15R, IL4R/IL13R/IL13RA1/IL13RA2, IL7R/IL7RA, IL9R, IL21R)

β-chain	Interleukin receptors (IL3R/IL3RA, IL5R/IL5RA) · GM-CSF

gp130	Interleukin receptors (IL6RA, 11/IL11RA, 27/IL27RA) · OSMR · LIFR · CNTFR

IL12RB1	Interleukin receptors (IL12R/IL12RB1/IL12RB2, IL23R23)

Other	other CSF receptors (EPO, G-CSF, Thrombopoietin) hormone receptor: GH · prolactin

Type II

Interleukin receptors (IL10R/IL10RA/IL10RB/IL22R/IL22RA2, IL20R/IL20RA/IL20RB, IL28R) · Interferon receptors (-α/β/IFNAR1/IFNAR2, -γ/IFNGR1/IFNGR2)

Ig superfamily

CSF1 · KIT · IL1 (IL1R1, IL1R2) · IL18R/IL18R1

IL-17 family

IL-17 (IL17RA, IL17RB, IL17RC, IL17RD, IL17RE)

S/T

TGF-beta (TGFBR1, TGFBR2)

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

Interleukin 20 receptor, alpha subunit

References

Further reading